Modeling & Simulation Scientist / Director

Hiring By - Biostaffic


Cambridge, Massachusetts - United States

Job Highlights

Not Disclosed


Posted 4 months ago
Job details

Beacon Hill Life Sciences is actively recruiting for a pharmacology Modeling & Simulation (M&S) Scientist/Director.

  • This is a perm opportunity that requires being on-site (hybrid) at least 3 days/week.
  • Location: Cambridge, MA

The M&S Director will drive strategy and provide leadership within modeling and simulation (M&S) function. Will apply knowledge and technical expertise to characterize systems biology, pharmacokinetics, and pharmacodynamics-related aspects facilitating research efforts across a diverse portfolio of diseases and therapeutic approaches.

Must be analytical, goal-oriented, and committed to maintaining the highest scientific and ethical standards. Strong communication skills and comfort working in a dynamic, cross-functional team environment are highly desirable.

Key Responsibilities:

  • Lead and drive modeling and simulation-based efforts from discovery to early development
  • Facilitate early research efforts by building systems biology-based mechanistic disease and therapeutic intervention models.
  • Explore the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile.
  • Develop and validate preclinical PK/PD/Biomarker/Efficacy models to elucidate quantitative PK/PD relationships.
  • Utilize preclinical ADME, pharmacology, and pharmacodynamic data to develop predictions for human efficacious dose.
  • Build and lead research-oriented M&S strategies from target engagement to disease-level quantitative systems pharmacology models.
  • Identify opportunities where model-informed drug development can advance the understanding of biology, pharmacological activity, and safety.
  • Ensure that supporting infrastructure (software, methods, consulting support, etc.) meets all expectations.
  • Engage in strategic communication with leaders, cross-functional leadership, and external stakeholders to facilitate M&S-related governance decisions.
  • Develop the Modeling and Simulation function within the medicine team.
  • Define, monitor, and manage short-term and long-term budgets.
  • Supervise, develop and mentor scientists within and outside of the M&S function.
  • Foster a culture of continuous learning and improvement.

Education and Experience:

  • Ph.D. with 10+ years of experience in pharmacokinetics, pharmaceutical sciences, or other related disciplines
  • Strong background in quantitative and qualitative research methodologies related to systems biology, pharmacokinetics, and PK/PD
  • Experience supporting drug discovery programs based on standard therapeutic modalities (small molecules, antibodies, and/or peptides)
  • Working knowledge of gene-based therapy approaches (gene regulation, RNA medicine, gene therapy) is desirable
  • Basic programming skills (e.g., R, Python)
  • Hands-on modeling experience using Phoenix Winnonlin, Gastroplus, and/or similar software packages
  • Experience managing direct reports is a plus

Beacon Hill is an Equal Opportunity Employer that values the strength diversity brings to the workplace. Individuals with Disabilities and Protected Veterans are encouraged to apply.

If you would like to complete our voluntary self-identification form, please click here or copy and paste the following link into an open window in your browser:

Completion of this form is voluntary and will not affect your opportunity for employment, or the terms or conditions of your employment. This form will be used for reporting purposes only and will be kept separate from all other records.

Benefits Offered?

  • No

Bonus Offered?

  • No

Travel Required?

  • No


  • Cambridge, Massachusetts - United States


  • Director

Global Experience Needed?

  • No

Specialized Experience Needed?

  • No

Apply before:

  • Apr 14, 2024
Company Overview
Beacon Hill Staffing Group
Beacon Hill Staffing Group

Current Openings: 0

Beacon Hill Staffing Group was founded to set a new standard in search, career placement and flexible staffing. Our niche brands provide direct hire, executive search, temporary staffing, contract consulting and temp/contract-to-hire solutions to emerging growth companies and the Fortune 500 across market sectors, career specialties/disciplines and industries. Over time, office locations, specialty practice areas and service offerings will be added to address ever changing constituent needs. Learn more about Beacon Hill Staffing Group and our specialty divisions, Beacon Hill Associates, Beacon Hill Financial, Beacon Hill HR, Beacon Hill Government Services, Beacon Hill Legal, Beacon Hill Life Sciences, Beacon Hill Solutions and Beacon Hill Technologies by visiting We look forward to working with you.
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