Modeling & Simulation Scientist / Director

Beacon Hill Life Sciences is actively recruiting for a pharmacology Modeling & Simulation (M&S) Scientist/Director.

• This is a perm opportunity that requires being on-site (hybrid) at least 3 days/week.
• Location: Cambridge, MA

The M&S Director will drive strategy and provide leadership within modeling and simulation (M&S) function. Will apply knowledge and technical expertise to characterize systems biology, pharmacokinetics, and pharmacodynamics-related aspects facilitating research efforts across a diverse portfolio of diseases and therapeutic approaches.

Must be analytical, goal-oriented, and committed to maintaining the highest scientific and ethical standards. Strong communication skills and comfort working in a dynamic, cross-functional team environment are highly desirable.

Key Responsibilities:

• Lead and drive modeling and simulation-based efforts from discovery to early development
• Facilitate early research efforts by building systems biology-based mechanistic disease and therapeutic intervention models.
• Explore the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile.
• Develop and validate preclinical PK/PD/Biomarker/Efficacy models to elucidate quantitative PK/PD relationships.
• Utilize preclinical ADME, pharmacology, and pharmacodynamic data to develop predictions for human efficacious dose.
• Build and lead research-oriented M&S strategies from target engagement to disease-level quantitative systems pharmacology models.
• Identify opportunities where model-informed drug development can advance the understanding of biology, pharmacological activity, and safety.
• Ensure that supporting infrastructure (software, methods, consulting support, etc.) meets all expectations.
• Engage in strategic communication with leaders, cross-functional leadership, and external stakeholders to facilitate M&S-related governance decisions.
• Develop the Modeling and Simulation function within the medicine team.
• Define, monitor, and manage short-term and long-term budgets.
• Supervise, develop and mentor scientists within and outside of the M&S function.
• Foster a culture of continuous learning and improvement.

Education and Experience:

• Ph.D. with 10+ years of experience in pharmacokinetics, pharmaceutical sciences, or other related disciplines
• Strong background in quantitative and qualitative research methodologies related to systems biology, pharmacokinetics, and PK/PD
• Experience supporting drug discovery programs based on standard therapeutic modalities (small molecules, antibodies, and/or peptides)
• Working knowledge of gene-based therapy approaches (gene regulation, RNA medicine, gene therapy) is desirable
• Basic programming skills (e.g., R, Python)
• Hands-on modeling experience using Phoenix Winnonlin, Gastroplus, and/or similar software packages
• Experience managing direct reports is a plus

Beacon Hill is an Equal Opportunity Employer that values the strength diversity brings to the workplace. Individuals with Disabilities and Protected Veterans are encouraged to apply.

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