Drug Discovery Chemist - Antibody Drug Conjugates

invoX is a research-driven global biopharmaceutical company using next-generation technology platforms to discover and develop innovative medicines that can change the lives of people around the world. Our vision is to be a leading global biopharmaceutical company with an advancing pipeline of products addressing the unmet healthcare needs of patients.

To help continue our growth and success, we are looking for a Drug Discovery Chemist - Antibody Drug Conjugates, to join our Protein Sciences team. You will be a highly self-motivated, independent, and creative Principal Scientist, with a background in synthetic chemistry and you’ll have significant experience in antibody drug conjugates / drug discovery and development. This is an exciting opportunity to play a key role in the development of innovative antibody drug conjugates from design, synthesis, characterisation to candidate selection. As invoX continues to grow, this is a compelling opportunity to work in a fast-paced business.

invoX is a wholly owned subsidiary of Sino Biopharmaceutical Limited, a Hong Kong listed global top 40 pharmaceutical company with more than 24,000 employees.

Key Responsibilities

• Designing and evaluating linker-drug payload constructs and bioconjugation methodologies to achieve the desired target product profiles.
• Developing in vitro and in vivo methods to assess stability, efficacy, pharmacokinetic and safety profiles of drug candidates in line with project goals.
• Overseeing and coordinating day-to-day research activities in collaboration with CRO partners to ensure the timely delivery of technical objectives.
• Reviewing in vitro and in vivo data to monitor progress and inform technical strategy and decision-making
• Drafting and reviewing research documentation, such as reports, presentations, publications, manuscripts, patent applications, and/or summaries. Dissemination of research findings to internal and external audiences through publication and presentation of research results. Translation of validated research data and processes into publications or patent applications.
• Maintaining a high level of familiarity with relevant scientific and technical literature with the ability to appropriately apply new developments to internal research projects.

Skills, Knowledge & Expertise

You will be skilled in the interpretation of in vitro and in vivo data to inform technical strategy and decision making and will be expected to function with a high degree of independence whilst working collaboratively within a multidisciplinary team, across organisations.

• PhD or equivalent in a Chemistry-related subject
• Relevant research experience, ideally involving significant time in an industry setting
• Expertise in synthetic chemistry with an emphasis on bioconjugation, ideally in the field of antibody drug conjugates
• Experience of the drug discovery process, ideally in the development of antibody drug conjugates
• Able to work successfully and confidently in collaboration with CROs, the management team, advisors, and consultants
• Excellent communication (both verbal and written) and interpersonal skills
• Ability to effectively present results, interpret in vitro and in vivo data, and draw conclusions regarding presented material
• Able to understand drug discovery project goals and methods and think critically and creatively to generate ideas to positively impact project goals

Why work for invoX?

We get things done, we keep things simple and we are driven by the science. We are ambitious so we work hard to create an environment where we can take smart risks. We want to be innovative so encourage debate and collaboration to challenge the usual way of doing things. We love our celebrations and socialising, which make invoX a fun and diverse place to work. And most of all, everyone has the opportunity to make a difference.

For this position candidates must be eligible to live and work in the UK