Senior Scientist, Cancer Cell Programs (Post-CAN Research)

Role Summary
Pfizer’s Oncology Research Unit (ORU) in La Jolla, California, is seeking a self-motivated and collaborative Senior Scientist to join the Post-CAN Research group focused on translating basic discoveries in the field of cancer cell biology into novel therapeutics.
The Senior Scientist will work within a collaborative team of motivated and scientifically rigorous scientists to conduct preclinical research and advance our clinical and pre-clinical drug programs in the field of cancer cell biology. Our ideal candidate will have a strong background employing state-of-the art approaches to gain a broader understanding of cell cycle and cell signaling in cancer biology. The candidate will translate basic research findings into therapeutic strategies, utilizing pharmacological and genetic approaches to formulate combination strategy, understand target mechanisms of action or/and resistance, and generate patient stratification strategies. The successful candidate will demonstrate a proven track record of scientific productivity as evidenced by scientific initiative and creativity in drug discovery and development or first author publications in scientific journals.
Role Responsibilities

• Utilize expertise in cell cycle or/and cell signaling to develop innovative strategies for understanding the role of cell cycle or cell signaling in cancer progression, drug resistance and immune modulation
• Design, execute and analyze/interpret experiments to advance mechanism of action studies, develop patient responder hypotheses, elucidate mechanisms of resistance, and identify rational drug combinations that can be translated to the clinic
• Work collaboratively with computational biology group to integrate complex data sets including ‘omic’ data in preclinical/non-clinical settings to deepen understanding of target biology
• Interface with groups of discovery biology, discovery technologies, computational biology, ADC biology, in vivo pharmacology, PDM, and DSRD to design experiments and interpret datasets to advance pipeline projects
• Proactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program
• Present research results and methodologies at routine meetings with immediate supervisor and/or project leader, project team meetings and other research forums
• Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific development.
  

Qualifications
Basic Qualifications

• PhD in Molecular or Cellular Biology, Biochemistry, Genetics/Genomics, Pharmacology, or related field with typically 3+ years of relevant postdoctoral experience in an academic or pharmaceutical/biotech environment
• Expertise in cell cycle biology and/or cell signaling as evidenced by publication in peer-reviewed journals
• Preference for candidates with a strong track record in cancer drug discovery and/or translational research focusing on cell cycle/cell signaling
• Demonstrated proficiency in a wide range of cell and molecular biology techniques and relevant assay detection technologies
• Strong ability to multi-task and work efficiently and productively in a fast-paced, highly collaborative in a diverse team environment with excellent communication skills and excellent leaderships skills
  

Preferred Qualifications

• Experience in translational oncology including preclinical identification and evaluation of biomarkers (pharmacodynamics, prognostic, and response predictive) and assessment of drug combination strategy
• Experience supporting IND study reports or writing relevant sections of IND study reports
• Extensive knowledge and understanding of other areas of cancer biology including but not limited to ADC biology, immuno-oncology, DNA repair, epigenetics and/or apoptosis
• Experience in use of chemo-genomic screens or/and CRISPR-based techniques for gene knockout, gene editing and as well as working knowledge of pooled CRISPR -based screening approaches
  

Relocation support available
Work Location Assignment: On Premise
The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development