Mathematical Modeller

Hiring By - Biostaffic


United Kingdom

Job Highlights

Not Disclosed

Mid-Senior level

Posted 4 months ago
Job details

A highly motivated, ambitious Mathematical Modeller is required to develop and analyse mathematical models that focus on the role of sortilin-mediated progranulin-related pathways in neurodegenerative diseases. This position is a unique opportunity to work in a dynamic environment and in close collaboration with Clinical Pharmacology and Modelling and Simulation department with one of the leading global Biopharmas, who are at the forefront of the application of model-informed drug development to clinical trials.

As the Mathematical Modeller you will be part of a multi-disciplinary, science driven team delivering modelling and simulation excellence to drug discovery and development through better understanding of the patterns and mechanisms in neurodegenerative disease. Responsibilities will include development, analysis and application of mathematical models based on available literature, in vitro imaging and clinical data. The newly developed mechanistic models will be a step towards enhanced quantitative understanding of the role of anti-sortilin pathways in increasing the progranulin (PGRN) levels and in regulating downstream pathways affecting neurodegenerative disease progression.

You will develop mathematical models and perform simulation studies to understand both the neurodegenerative disease processes and anti-sortilin drug pharmacodynamics. The insight into pharmacodynamics will contribute to the generation and testing of mechanistic hypotheses, and Virtual Patients will be also used to inform optimal clinical study design including selection of key biomarkers and optimal patient subpopulations. Additionally, there will be an opportunity to identify, suggest and lead development of novel approaches to utilizing in silico quantitative systems pharmacology (QSP) and integrating it with genomic sciences to inform preclinical and clinical neuroinflammatory drug development.

This position represents an exciting opportunity for a professional with a PhD in Applied Mathematics, Mathematical Biology, Engineering, Physics, Computational Biology, Modelling and Simulations, Neuroscience, Pharmaceutical Sciences, or other related discipline, and a demonstrated strong publication record.

Fixed-term contract until 30 September 2027

The successful person will need to work on site for a minimum of 4 days per week

Benefits Offered?

  • No

Bonus Offered?

  • No

Travel Required?

  • No


  • United Kingdom


  • Mid-Senior level

Global Experience Needed?

  • No

Specialized Experience Needed?

  • No

Apply before:

  • Apr 11, 2024
Company Overview

Current Openings: 0

SRG is the leading recruiter of permanent and temporary talent for scientific, clinical and engineering businesses. We are the largest life-science recruitment company in the UK, number 5 in EMEA, and number 8 globally. SRG is powered by Impellam, a connected group providing global workforce and specialist recruitment solutions. To learn more about Impellam Group, visit: SRG was formed in 1990, focusing purely on the life-science industry. With sites across the UK, Ireland, Europe, and North America, our specialised teams now align their knowledge and expertise with the product life-cycle across Pharmaceuticals, Biotechnology, Chemicals, MedTech and FMCG. We place over 800 professionals into permanent positions each year, and currently employ 1,800 temporary contractors/associates across the STEM sectors. People-first STEM recruitment SRG speaks your language. With over 100 ‘expert-to-expert’ staff — made up of experienced scientists, engineers, and clinical, and tech professionals — we implicitly understand the main challenges of your industry. Leaving complex strategies and tired jargon behind, we devise simple, easy-to-digest solutions to your most pressing talent pain points. And with an eye on the latest developments in STEM and recruitment, we’ll help you anticipate and prepare for the future of work. Helping STEM organisations build a talented workforce SRG goes beyond the traditional scope of a recruiter. Forging sustainable, mutually beneficial partnerships with clients and candidates alike underpins everything we do. This is why we strive to provide ongoing support — to clients as they build a talented, engaged workforce for the future, and to candidates as they follow their desired career path.
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